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Active research projects

“Ethically and socially responsible governance of research biobanks in Latvia: analysis of opinions of public, donors and researchers”

The aim will be obtained by the study of the publics’, donors’ and researchers’ attitudes, concerns and trust in biobanking and analysis will be performed how the concerns and needs raised by the public, donors and researchers can be adequately dealt by the normative framework to finally improve research biobank governance and drive public policy decisions by developing written recommendations based on the results of the study.

Principal investigator: Assoc. prof. Signe Mežinska

Research is funded by the Latvian Council of Science project No. lzp-2018/2-0171.

 

"Interplay of Environmental and Genetic Factors in the Immunologic Mechanisms of Thyroid Autoimmune Diseases"

Aim of the project is to analyze susceptibility genetic variants for Autoimmune Thyroid Diseases (AITD) in patients with Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) according to precision medicine concept and to investigate the interaction between them and particular environmental factors including selenium intake and status, stress, lifestyle habits and other triggers in the occurrence of different T helper pathways and cytokine patterns.

Principal investigator: Assoc. prof., Dr. med. Ilze Konrāde

Research is funded by the Latvian Council of Science project No. lzp-2018/2-0059.

 

„Development of rare disease infrastructure for diagnostics and research”

The main aim of the project is to develop biological material and associated data collection from rare disease patients and their relatives, to improve diagnostics of these diseases in Latvia and ensure resources for rare disease research in the world. It is planned to involve rare disease patients and their blood relatives in Genome Database of Latvian population. The collected biological materials and data will be used for diagnosticsor if such diagnostics is not available in research projects as well to ensure diagnostics for these patients within the famework of research project.

Principal investigator: Prof. Jānis Kloviņš

Patient recruitment is supported by Genome Database of Latvian population.

Approval by Central Medical Ethics Committee No: 1/18-06-19.

 

“Exploitation of extracellular vesicles for precision diagnostics of prostate cancer”

The overall aim is to establish technically and clinically validated non- invasive tool for PCa diagnosis ang prognosis based on the analysis of EV counts and molecular cargo in patients` biofluids.

Principal investigator: Dr. Biol. Aija Linē

Research is funded by ERA-NET TRANSCAN-2 Joint Transnational Call for Proposals 2016 (JTC 2016) project application “Exploitation of extracellular vesicles for precision diagnostics of prostate cancer”, patient recruitment is supported by Genome Database of Latvian population.

 

"Investigation of interaction of smoked dietary products with gut microbiome”

The main objective of the project is multidimensional investigation of the impact smoked food especially fish consumption exerts on human gut microbiome to gain insight in the responding functional pathways and metabolic consequences.

Principal investigator: Dr. biol. Ineta Kalniņa

Research is funded by the ERDF No.1.1.1.2/VIAA/1/16/128 project with the same title.

Approval by Central Medical Ethics Committee No:  1/18-06-07.

 

„Molecular markers of pituitary tumor development, progression and therapy response”,

 The main objective of this project is to investigate molecular determinants of pituitary adenoma development and progression and to identify the crucial factors linked to variability in clinical outcome that could further be applied as biomarkers for improvement of pituitary tumor treatment therapies.

Principal investigator: Prof. Jānis Kloviņš

Research is funded by the European Regional Development Fund (ERDF), Measure 1.1.1.1 “Industry-Driven Research”, Project No: 1.1.1.1/16/A/066 project.

Approval by Central Medical Ethics Committee No: 2/18-02-21.

 

„Investigation of interplay between multiple determinants influencing response to metformin: search for reliable predictors for efficacy of type 2 diabetes therapy”,

The objective of the project is to explore underinvestigated factors characterizing response to metformin with the aim to identify reliable biomarkers of efficacy and tolerability of metformin in the treatment of type 2 diabetes.

Principal investigator: Prof. Jānis Kloviņš

Research is funded by the European Regional Development Fund (ERDF), Measure 1.1.1.1 “Industry‑Driven Research”, Project No: 1.1.1.1/16/A/091 project. 

Approval by Central Medical Ethics Committee No: 1/16-05-12.

 

„Development of unified drug monitoring model for patients with inflammatory bowel diseases using imunologic, molecular, biological and morphological methods"

The main aim is to study individual thiopurine metabolism and therapeutic drug govenance, using imunological, clinical, molecular and mophological methods, impact on disease progression in patients with inflammatory bowel diseases.

Principal investigator: Dr. Polīna Zaļizko

 Approval by Central Medical Ethics Committee No: 3/18-02-21

 

“Walk healthy”

The aim is to improve physical abilities, diabetes control and lower complication risks with regular physical activities programm and interval training method in type two diabetes patients. Project will also help to evaluate use of mobile devices and efectivity in training monitoring in comparison with physiotherapist guided training.

Principal investigator: Dr. med. JeļizaApproval by Central Medical Ethics Committee No:veta Sokolovska

Funding: LLC “Mikrotīkls” donation in framework of Fund of University of Latvia project.

Ethical approval from University of Latvia Cardiology and Regenerative Medicine Insistute, Ethics committee of clinical-physiological, drug and pharmaceuticals research, approval  No: 28.06.17 - Prot. 6